ea0065p231 | Metabolism and Obesity | SFEBES2019
Laforest Sofia
, Denver Nina
, Homer Natalie ZM
, Durocher Francine
, Walker Brian R
, Andrew Ruth
, Tchernof Andre
Background: Adipose tissue dysfunction could partially explain the well-demonstrated association between obesity and survival in breast cancer (BC). Oestrogen and glucocorticoid concentrations and their respective activation enzymes, oestrogenic 17β-hydroxysteroid dehydrogenases (17βHSDs) and aromatase, and 11βHSD1 are increased in adipocyte hyperplasia and hypertrophy, supporting the hypothesis of a potential role for locally generated steroids in obesity-assoc...